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However, if puberty has not started by either age 14 (girls) or 15 (boys) and one or more of the non-reproductie features mentioned belowe is present then a referral to reproductive endocrinologist might be advisable.

The exact genetic nature of each particular case of KS / HH will determine which, if any, of the non-reproductive features will occur.

This will lead to a fall in testosterone or oestrogen levels and infertility.

Kallmann syndrome has an additional symptom of a total lack of sense of smell or a reduced sense of sense of smell which distinguishes it from other forms of hypogonadotropic hypogonadism.

Treatment for both males and females is normally required life long.

If left untreated people with Kallmann syndrome will have poorly defined secondary sexual characteristics, show signs of hypogonadism, almost invariably be infertile and be at increased risk of developing osteoporosis.

A range of other physical symptoms affecting the face, hands and skeletal system can also occur.

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